Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Blog Article

A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their Desk Lamp in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL.Several compounds exhibited antitubercular activity Drapes (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.